Modality or treatment option | Response rate (%) | Recurrence rate (%) | Comments | Study Design |
Preventive silicone sheeting as postsurgery care | 0 - 75 | 25 - 36 | Multiple preparations available; tolerated by children | Review of multiple case studies [8] |
Postsurgical intralesional corticosteroid injection | 0 - 100 | 0 - 100 (mean 50) | Patient acceptance and safety | Review of multiple case studies [9] |
Postsurgical topical imiquimod 5% cream | 80 | 28 | May cause hyperpigmentation, irritation | Case study [10] |
Cryotherapy | 50 - 76 | 23 | Useful on small lesions; easy to perform | Review of multiple case studies [9] |
Intralesional corticosteroid injection (triamcinolone acetonide 10 - 40 mg per ml at 6 week intervals) | 50 - 100 | 9 - 50 | Unexpensive; available | Review of multiple case studies [9] |
Surgical excision | variable | 50 - 100 | Review of multiple case studies [9] | |
Triple keloid therapy” (surgery, corticosteroids, and silicone sheeting) | 88 at 13 months | 12.5 at 13 months | Time intensive; expensive | Case study [10] |
Postsurgical interferon alfa-2b 1.5 million IU intralesional injection twice daily for 4 days | 30 - 50 | 8 - 19 | Expensive | Review of multiple case studies [9] |
Pulsed dye laser | 30 - 40 | 30 | Expensive; variable results depending on trial (controversial) | Case studies [11] [12] |